Koide Laboratory - Synthetic Protein Science
We aim to advance the knowledge of how proteins and protein interaction networks work by “synthetic” approaches, i.e. designing and making proteins with novel function. This approach in protein science critically tests our understanding of principles that govern protein structure, function and evolution, and it challenges our creativity.
We are now capable of producing highly functional synthetic proteins within weeks. Structural and functional analysis of synthetic proteins not only critically evaluates the effectiveness of our design strategies but also provides broader insights into the molecular mechanism and evolution of protein form and function. Knowledge gained from the synthetic approach complements and very often significantly expands the view from classical studies of natural proteins.
Synthetic proteins serve as novel and transformative tools for basic and translational research in biology, medicine and beyond. We are particularly interested in applying synthetic protein science to the following areas of biology and medicine:
- Signal transduction mediated by tyrosine phosphorylation
- Structural biology
- Cancer biology
- Synthetic biology
- Drug discovery
- Systems biology
March 2016 - After 14 years at the University of Chicago, the Koide lab is relocating to New York University Langone Medical Center in Manhattan.
February 2016 - Our paper on monobody inhibitors directed to the SH2-kinase interface of Bcr-Abl is published in JBC. They potently induce apoptosis in CML cells.
February 2016 - Our paper on the development and structures of anti-histone PTM antibodies is published in PNAS. These antibodies exhibit unprecedented "antigen clasping", conceptually similar to affinity clamping. Highlighted on the CBC site and BioCentury Innovations.
November 2015 - Our paper on monobody-enabled investigator of Prdm14 structure, interaction and function is published in eLife. This is a collaborative project with the Wysocka lab at Stanford. Congratulations!
August 2015 - Fern and David have received their Ph.D. degrees. Congratulations!
August 2015- Jay (Berkeley), Chris (Birmingham) and Theresa (MIT) are off to grad schools. Good luck.